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A Global Leader in Tick-borne Diseases

For over 25 years, IGeneX has been the global leader in the research and development of tests that accurately detect Lyme disease, Relapsing Fever, and other tick-borne diseases. Tick-borne illnesses can affect every part of your life, and without effective diagnosis and treatment, symptoms can often worsen and progress into severe and even life-threatening health issues. And when you can't find the cause or a way to get better, your quality of life suffers. At IGeneX, we make it our singular mission to offer best-in-class testing for tick-borne diseases that delivers the most comprehensive and accurate results possible, so you can find the right treatment path to restore your health and get back to enjoying your life. Starting now.

We are committed to unraveling the mysteries of Lyme disease and associated tick-borne diseases. Our scientists work directly with physicians, universities and other scientists that specialize in Lyme to continuously evolve our testing criteria and accelerate the development of new and increasingly more effective diagnostic methods.


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Lyme disease has become increasingly challenging to diagnose, making accurate and reliable testing even more essential to inform and support physician diagnoses. However, recent research has revealed that the standard two-tier testing recommended by the Centers for Disease Control and Prevention (CDC) as well as a growing number of new tests can often lead to false positive and negative results. Diagnosis is made even more challenging by the fact that Lyme disease symptoms closely resemble other diseases. In fact, Lyme disease is often called "The Great Imitator" because its symptoms mimic so many other illnesses, including Chronic Fatigue, Fibromyalgia, Rheumatoid Arthritis, Multiple Sclerosis, Parkinson's disease, ALS, Depression and Alzheimer's disease.


Click Circles Below to learn More About Testing Options Available for Each Pathogen


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Lyme ImmunoBlots IgM and IgG

The Lyme ImmunoBlot is a qualitative immunoassay in which antibodies specific to the B. burgdorferi antigens on a membrane strip are visualized. It is a qualitative test and is more sensitive and specific than the ELISA, IFA and traditional Western Blot tests. In early or late stage of the disease when antibody levels are very low, ImmunoBlot can be positive whereas ELISA and IFA tests can be negative. This test must be used if the Lyme IgG/IgM antibody serology or Lyme IgG/IgA/IgM IFA is positive or equivocal.

TBRF ImmunoBlots IgM and IgG

The Tick-Borne Relapsing Fever (TBRF) ImmunoBlot is a qualitative immunoassay in which antibodies specific to the TBRF Borrelia antigens on a membrane strip are visualized. It is a qualitative test and is more sensitive and specific than the IFA and traditional Western Blot tests. In early or late stage of the disease when antibody levels are very low, ImmunoBlot can be positive whereas IFA tests can be negative.

Click Image to Learn More About the Lyme Immunoblots IgM and IgG

Click Image to Learn More About the Lyme Immunoblots IgM and IgG

Principle

The Lyme ImmunoBlot assay is based upon an antigen-antibody complex formation in the following steps:

  1. Binding of anti-Borrelia specific antibodies in human serum to the ImmunoBlot strip. ImmunoBlot strip is a membrane strip with fixed B. burgdorferi recombinant antigens on it.
  2. Binding of enzyme labeled anti-human IgG or IgM antibodies to the human anti Borrelia antibodies bound to fixed B. burgdorferi antigens on the membrane.
  3. Reaction with BCIP/NBT, a chromogenic substrate with bound antibodies on the strip. A dark purple colored precipitate (band) develops on the antigen-antibody complexes.
Click Image to Learn More about the TBFR Immunoblots IgM and IgG

Click Image to Learn More about the TBFR Immunoblots IgM and IgG

Principle

The TBRF ImmunoBlot assay is based upon an antigen-antibody complex formation in the following steps:

  1. Binding of anti-TBRF Borrelia specific antibodies in human serum to the ImmunoBlot strip. ImmunoBlot strip is a membrane strip with fixed TBRF Borrelia recombinant antigens on it.
  2. Binding of enzyme labeled anti-humanIgG or IgM antibodies to the human anti TBRF Borrelia antibodies bound to fixedTBRF Borrelia antigens on the membrane.
  3. Reaction with BCIP/NBT, a chromogenic substrate with bound antibodies on the strip. A dark purple colored precipitate (band) develops on the antigen-antibody complexes.